WebDec 20, 2024 · Tight regulation of inflammation is very important to guarantee a balanced immune response without developing chronic inflammation. One of the major mediators … WebApr 15, 2004 · Because the rescue phenotype of mafG::mafF::keap1 triple compound mutant mice is similar to that of the nrf2::keap1 compound mutant mice, we conclude that small Maf proteins are indispensable components for Nrf2-dependent transcription in vivo. These results further support the contention that Nrf2-small Maf heterodimers serve as …
Qualifications for the MAFF - NACVA
WebNov 1, 2012 · NF-E2-related factor 2 (Nrf2) is a key transcription factor that is critical for cellular defense against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small … WebAug 25, 2024 · MafF is a known interacting partner of Nrf2 that plays an important role in the regulation of antioxidant gene expression such as glutathione S-transferase alpha2 (GSTA2), NAD(P)H:quinone oxidoreductase (NQO1), γ-glutamate cysteine ligase (γ-GCLC and γ-GCLM) and heme oxygenase-1 (HO-1). blairs ferry senior apts
NRF2/MAFG - geneXplain
WebApr 4, 2016 · NRF2 is well known to be responsible for regulating a battery of antioxidant and cellular protective genes, which requires formation of heterodimeric complexes with a small Maf protein (MAFG,... NRF2 is a basic leucine zipper (bZip) transcription factor with a Cap “n” Collar (CNC) structure. NRF2 possesses seven highly conserved domains called NRF2-ECH homology (Neh) domains. The Neh1 domain is a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins (MAFF, MAFG, MAFK). The Neh2 domain allows for binding of NRF2 to its cytosolic repressor Keap1. The Neh3 domain may play a role in NRF2 protein stability and may act as a tra… WebOct 1, 2012 · The MAF recognition element (MARE) sequence typically comprises TPA-responsive element (TRE) or cyclic AMP-responsive element (CRE) [24] core motifs that … fqhc university